ok, now you are freaking confusing the shit out of me. HOW THE FUCK ARE THEY USING IT AS MAIN FEATURE OF ANDROMEDA? HOW? in what god forsaken way?
again, HAVING AN IMPLANT IS NOT A FUCKING SYNTHESIS. ITS HAVING AN IMPLANT. its NOT altering you constantly, anymore than your fucking omnitool as a sentinel player is altering you, any more then all the various bullshit abilities iron man pulls by wearing his various suits or lets go with performance drugs we have today, right now - SAM is litteraly an advanced targeted performance drug when it comes to Ryder's combat abilities.
and again, Andromeda initiative skedaddles to adromeda BEFORE events of ME3. they have no idea of the outcome of Reaper war, its kinda the point of setting the game in Andromeda in a first place, so that they don't have to pick an ending to work with. the initiative is there as a backup in case the war is lost. and people in Andromeda? are NOT affected by the synthesis wave, should it happen EITHER. cause that's only in milky way galaxy.
but back to pathfinders and their AI partners which are IMPLANTS.
https://masseffect.fandom.com/wiki/Pathfinder not. synthesis. at all. not even close.
https://masseffect.fandom.com/wiki/SAM they are LITTERALY advanced biotic implants AS PER LORE. they ENHANCE what's already there, they are NOT changing it in any way. and those implants can be removed, transferred, etc - pretty much at will. there are examples of pathfinders LOSING their mantle should rider make certain choices and they go back to being regular old representatives of their species. literally anyone can be a pathfinder, heck one of them can become one without any training at all, because they just happened to be next in line in a chain of command.
your precious catalyst would NOT have been making such a big fucking deal out of synthesis if it was what YOU think is synthesis. becasue guess what? WE ALREADY HAD IT. ergo. synthesis is something VERY different.
and now, Shepard is NOT the messiah and the only reason anything changes, that is just such a ridiculous take, especially since, again AS PER LORE - Catalyst exists as a work of multiple cycles and its not like Reapers gave any of the previous cycles enough time to figure it out on their own, they just swooped in the moment they detected AI existing, as per lore.
/sigh.
whatever. believe whatever the hell you want to believe. doesn't matter. its a video game at the end of the day.