I'm gonna go ahead and assume you meant Signet of Inspiration (and not Sigil)
If this is the case then think about this: 6x Runes of Lyssa -> Time Warp -> Signet of Inspiration
I checked your build since I've been running one somehow similar to that. Just a question, why do you have sigils of corruption on every weapon set? I suppose you have a separate set of weapons (with other sigils) that you switch into once you reach 25 stacks? One other thing, since your build is high on toughness, wouldn't you gain more from using 6x Runes of the Undead?