If you are filling up your inventory so much that you feel the need to go back so often, maybe you should download an item filter add-on and stop picking up all the crap. About the only things I pick up now are specific pieces I want to orb for better stats or uniques I know I can sell. Well, besides things like currency and maps obviously.
I would say get an item filter mod and get familiar with poe.trade. You won't need to worry about picking everything up and can just focus on what you need and what you know you can sell. Back when I played PoE, I was making about 1-2 ex a day just casually throwing things up for trade. If you got really serious about it, learned a good farming build and had the right maps/mods/etc, you could be making 10 times that or more, easily.