It's usually done with Isaac, since he's the vanilla character with no abilities. Everyone else starts with something you can't get rid of - extra damage, extra speed, extra health, Whore of Babylon, etc. Well, it assumes you never use the D6, of course.
And people have done it. There are no rooms where you are guaranteed to take damage. I've seen examples of all of these rooms, and every single one of them gives you a way out.
A rather weak steam sale for me. Got more Stuff from Amazon, Greenman Gaming and GamesLoad this time.
Steam:
Darksiders Franchise
Dawn of War Franchise
Other sites:
XCOM, Hitman, Dawnguard, and some other stuff. Steam deals on Games < 2 years old where terrible this time.
Anyone else kind of bummed now that all the sales are done? I have to reminf myself to not check all the sites every few hours for a new "deal" to pop up. Oh well, time for new back log game play.