No way Palin would run again. She's (ironically) smarter than that as she knows she can make more money via commenting than running.
She'll just end up doing what she did last election, go on a "tour" of America that's funded by people wanting her to run, and then when she's done she'll say she's not running this year - just to get a free cross-country trip.
Definitely believe it will be Hillary on the Dem side though. Repubs will sadly still not have learned anything by then, and will instead - at best - have a latino male running for pres.
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Jeb Bush will try for the repub nomination, if even just for the purpose of trying to restore dignity and respect their family name. Though I doubt he even get the Repub nominee, as I believe the Bush name is faaaaaar too entrenched within a horrible reputation of GW for there to be enough confidence behind it.