Skyrim, couldn't really grip me and the animations, interface and combat were horrible imo.
Darksiders, boring gameplay and over-the-top "epic" story and characters.
The Witcher 2, though I wouldn't say it was bad, just overrated. It certainly looked nice.
Mass Effect 2 was worse than 3 imo, though I also enjoyed it.
Limbo was also overrated.
Minecraft consumes too much time for the enjoyment it brings for me.
Deadlight, though I'm not sure if this is a "popular" title.
Civilization 5 is neither immersive nor exciting. I'll rather play other strategy games.
But of those listed, Darksiders and Civ5 is the only one I could say I didn't really enjoy it. The others were alright or good, but not as good as you would think after visiting the internet.
EDIT: Warhammer 40k Dawn of War 2 is in the same category as Darksiders.