Everything is up in the air obviously, but the bosses I consider to be 1 - 10 shotted by some of the top contenders: Hans/Franzok , Gruul and Beastlord. Beastlord less likely, because that fight can be punishing if the tuning numberwise is higher, but we obviously can't know for certain.
Roadblocks to the top contenders not counting Blackhand: Blast Furnace, Iron Maidens (dat last portion doe), and up in the air I would say Kromog could be demanding.
Everything I didn't mention I expect it to be decently challenging for these guilds, but not too much, or atleast not as much as the ones stated above.
Expecting a lot from Paragon and Method, but won't be surprised if the Russian guild comes out on the top 3.