=Affixes=
-In general, affixes should not trigger out of combat. You should never have to stop because you're boxed in by Split Personality images on the stairs to Umbric. Neither should you have to crawl at a snail's pace when Desynchronized kicks in but you have already cleared the area.
-Ashjra'kamas' on use ability should clear all affixes while it is active and prevent them from triggering.
-The 2nd affix from the Mask should not be tied to a specific area, rather it should allow a wide range of combinations therefore preventing Leaden Foot / Split Personality combo from being up week after week.
=Mobs=
-In general, bosses should not cast sanity-draining abilities more often than they are able to be interrupted.
-Burrowing Tentacles should not have a damage immunity upon erupting from the ground after burrowing.
=Roleplay=
-Roleplay should never prevent you from advancing in timed content. Haven't you learned this from M+?
=Masks=
-Mask of the Long Night should be adjusted so that it does not affect the extra sanity gained from research. At the moment the sanity reduction from it is to steep to justify the extra mementos gained.
Feel free to share your own tips for Blizzard. The more feedback they get, the better Torghast will be.