There's some talk that a Biden administration with a Democratic Senate might sweep in and either remove the zeroed out mandate before the case is ruled on or, depending on how the ruling is applied, afterwards.
That said, the first blockbuster ruling this court makes is going to be politically explosive. We're currently staring down what amounts to an institutional vs. cultural crisis in this country where our institutions are increasingly far out of line with what the populace wants. Nullification and court stacking are likely responses, but this could get very ugly very fast.