It might not be known to the current generation, but Resident Evil 5 was actually monstrously controversial (rivaling Grand Theft Auto) back during its reveal and release back in the day.
A recap:
People back then were outraged at its depiction of a white protagonist gunning down natives in what was considered an extremely unflattering view of rural Africa, where said natives were depicted as animalistic killers (and swearing constantly in their native tongue). It actually got so out of hand that in the release, Capcom added some ethnic minorities, namely other whites and Hispanics, into the enemy roster that weren't seen in the early trailers. This ironically did not help matters, as people got more upset with the disturbing scenes of the African natives enacting torture and genocide upon said minorities; there is actually a rare enemy in the game, who is depicted in the early cutscenes as a minor antagonist, rallying the Africans to his cause to commit said genocide all the while shouting grossly xenophobic spiel in Swahili.
A while into the game, the protagonists run into enemies that caused even more controversy for racist insensitivity, namely African natives that have degraded to literal tribalism with spears, loincloths and shields.
While it's unknown how much this affected Resident Evil 5's sales or success, it was definitely not something that was just brushed off and haunts the game's legacy to this day.
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Why this matters now? With the absolutely smashing success of the Resident Evil 4 remake, fans were intensely speculating if Resident Evil 5 would be remade, as it is a game (comparitively to OG RE4 remake) that has not aged particularly well. Resident Evil 4's Separate Ways recent DLC more or less confirmed an RE5 remake with a tease at the end.
The problem with the African setting and how it can't be changed easily is just how ingrained it is into the Resident Evil mythos. Africa is a central place in the lore and even things like those tribal men and the ethnic genocide have explanations for their being laid out in files and notes. So it's not like Capcom can just remove these so easily. But regardless, do you think it's just too offensive? People as of 2023 are WAY more sensitive and prone to cancellation than they were in 2009.