Nah, Blizzard has never shyed away from making tier set bonuses around unused talents to give them a new lease of life. So they can literally pick whatever they want from the tree and make it around that; in either case, there is a plethora of new build potential with these trees so I wouldn't be surprised if they got a little wacky with the tier sets to follow suit.
Especially since these trees/tier sets are going to be our "patch power"!