Anyone making any claims of such knowledge is doing just that; making claims. And citing their own opinion to justify it.
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Ah...the smell of condescension. I've never heard of any scientist worth his PhD to claim to know what is impossible. Indeed such a word was never part of the vocabulary, as it indicates a very closed mind. (Thank the gods or whoever for paradigm shifts.)
To know what will ever be possible and impossible..why you'd have to be...well, psychic.
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*hairy eyeball*
That word "you" is a lexical ambiguity.