I used "lockouts" also as a metaphor, to also mean that you can't easily replace someone for >m+24 therefore: for obscene levels of difficulty on 5man: toxicity is also more problematic than on easy modes (I could also argue that 5manning itself is overrated because it easily produces brutal metas of a few specs but that's another topic).
If you only do the first bosses of mythic raiding: you didn't do it at all so it's practically off topic (but even if you do try to do those with pugging: it will also be very annoying compared to just replacing the toxic people on easy modes easily).