I was thinking this spec and glyphs:
http://talent.mmo-champion.com/?deat...3&version=9767
The rotation would be Icy Touch > Plague Strike > Blood Strike > Howling Blast > Pestilence (which is what i been using for months)
With Glyph of Disease, after the rotation I listed above.. use Howling Blast whenever not on cooldown or Obliterate when HB is on CD. Pestilence when you need to refresh your main target's disease and continue to spread, along with 5/5 Blood of the North. Basically my idea is that after using Icy Touch and Plague Strike once I will never have to use them again on that target. That would free up a frost and unholy rune for extra howling blasts and obliterates.
Now to decide if I want to start raiding again since there is a new instance. :P
Oh.. for the person who was talking about Lichborne, for me even on live I never really used it for the 25% miss feature. It was always a self heal to help out when people are having to move around. If I find that I am runic starved during fights I will put that point some place else.