Definitely but know that there ARE limitations in the Vanilla game for pure good guys or pure bad guys. For that there's mods. The Thieve's guild can be seen as bad, the Vanilla game has no way to take care of them but there's a Destroy the Thieve's Guild quest available on the Nexus. Also, Daedric quests for the most part are super evil and the things the Princes make you do are undeniably bad; there's also mods for these to where you don't have to sacrifice your buddies to get somewhere.