David Brin basically rips on the concept of Prime Directive with his Uplift Series.
In the universe of the books, very few alien civilizations have naturally developed, instead relying on patron races to biologically and/or technologically uplift other alien species.
Humans are an exception, we naturally evolved (being 'wolflings') and would have been uplifted technologically by another alien species if it weren't for the fact that we already began the process of uplifting chimps and dolphins. Although we're not as advanced as other alien species, the fact that we naturally evolved actually made us far more mature as a species as we've been aloud to make certain mistakes and learning from them.