First of all, I'm not advocating laziness, or trying to dumb down things. However, there's such a thing as quality of life in computer gaming, and that's what got me thinking about this.
EDIT: Also, and this is important: I envisioning this kind of a system for a Diablo-style game, not Diablo 3, and I'm not saying it would necessarily replace the current clicking control system, but rather add to it as an alternative.
Diablo-style games are clickers, and I'm sure Diablo 3 was kept as a clicker game partly to keep in line with the Diablo family. Thus, I'm not really suggesting that Diablo 3 itself would be given this style of control, but rather musing about what it would be like to have a game like Diablo 3 with these kinds of controls.
This system would mostly work with a Diablo style camera, ie. fixed bird's eye view.
The premise is very simple: basically you would not click to (left button) attack or to move, but in fact those actions would be automatic.
You would move your mouse cursor in the world, and your character would move with the cursor. This would also allow for a system where the distance of your cursor from your character could also determine your character's movement speed (walking, running, sprinting), which in turn could allow for speed-related abilities.
When you would mouseover an enemy, your character would attack that enemy with your left mouse attack. You could use other quick buttons and rightclick as you do now. You could even have abilities which require you to push and hold a quick button for some effect to be on, since you wouldn't have to push leftclick at all.
Obviously looting could still be done with leftclick.
This mode could be turned on and off, to go back to the normal clicker system. Also, it could be suppressed and toggled during the game, with for example CTRL, so that you could use your mouse normally.
What would this take away from the Diablo experience? Well, I for one don't see any huge repercussions as far as the level of difficulty of play goes. It would save mice though, I can tell you that.
Thoughts?