For some odd reason i can no longer mouse target, anyway to fix this besides using tab have bad experience using it
log out then back in.
I think I've had it happen to me a couple of times when I alt-tabbed, and as suggested log in and out sorts it out. There are quite a few games who dislike our alt tabbing habbits try to avoid it if the bug repeats it self or just relog each time.
I ended up rebooting forgot to mention i had logged out but thanks appericate it