depends on whether they have fully physically transitioned(which was not an option on a poll, so I picked none of them). wouldn't make me care for them any less, but if they didn't have a full reassignment surgery (and or not planning on having one), I just wouldn't be interested in physical relationship with them. which basically means we'd have to either remain friends or cut ties (and if I cared for them, I'd rather stay friends)
I consider it part of the physical attraction/preference package.
P.S. I'm not interested in having children, but even if I were, there's always a possibility of cis person being infertile, so its not like proper innards guarantee children either.