Originally Posted by
Tehr
Tombstone is hot garbage because it gives you a pretty mediocre shield at the cost of a ~50% reduced cooldown on Vampiric Blood. Even the active effect of Vampiric Blood aside, the shield you get from Umbilicus Eternus is almost always better than Tombstone in an AoE situation. Tombstone also requires that you dump extra GCDs to recoup your Bone Shield stacks (the RP you gain from it makes it net neutral in RP) so you have a small window of vulnerability.
Blood Worms are also hot garbage. If you're uncomfortable taking Blooddrinker then you can take Heartbreaker, but Blooddrinker is still superior in almost all realistic scenarios.
I'd use Sephuz at all times, and then swap between Soul and KJBW depending on the dungeon and affix combo. Keep in mind to NEVER equip or unequip Soul during a dungeon (except in very rare circumstances), because you have to run out of the dungeon to talent Rune Tap, and unequipping Soul also takes away Foul Bulwark, leaving you without a T6 talent. I personally use Sephuz for all trash, and all boss fights with an add that can be stunned/gripped or an interrupt. The dream legendary combo is Chest/Sephuz for most trash packs, especially on Fortified weeks, and Shoulders/Bracers for boss fights with no way to proc Sephuz. I consider Soul, Belt, and Cloak to be niche legendaries that are incredibly strong if you make full use of their effects, but otherwise quite weak.