Disclaimer: Let's try not to derail into things like race and religion beyond what is strictly necessary to provide context!
I'm not trying to bait a race or religion discussion, but I have a comfort range when it comes to cross culture interactions. I've spend enough time in China that I've had to become familiar with some things, including how grating it can be when someone just goes their own way like a bull in a China shop. Where I try to tread carefully though is Central Asia and the Middle East, because I'm agnostic and I feel it is the equivalent of being unable to see a common ground.
This came up tonight because of the virus here. A friend got the heck out and went home to a Central Asian country. I went to wish him good luck and good health, but he is Muslim and I'm vaguely aware that just wishing good luck might be graceless without including Inshallah. Since I'm agnostic, I felt pretty darned awkward adding it and I'm not sure I used it correctly; however, if I were in Italy I'd wear proper clothing to visit churches, and if someone who wouldn't recognize Gesundheit sneezes I'll say "bless you".
How do you guys deal with the cultural awkwardness of such things?