So, I was pondering this today. The enhancement simulator is a machine. It isn't going to have reaction times as long as a human does, it doesn't have visual distractions or information overload. Or that moment of indecision when you try to figure out which item should be next in your rotation. I wonder how much of a DPS reduction being a human being is versus being a simulator.
Lets assume the fight is Patchwerk and there's no moving. You just stand a deliver. I'm guessing maybe an 8% reduction. It is really hard to say because there's a lot of variation in what the log parses seem to say.