Originally Posted by
Rasuth
As long you as you don't have to maintain high threat you could "tab-pestilence". That would work something like this (Considering 3 mobs A, B and C):
1. Outbreak on A.
2. Pestilence to spread diseases.
3. [AoE via HS or BB, DnD if off CD.]
4. less than 5 secs of diseases on your target? Hit "tab", you are targeting B or C now, pestilence
5. Tab again to pestilence once more or apply diseases to B/C manually.
6. go to 3.
Might feel weird, but I believe in multi target situations you can up your survivability by using Blood Runes for maintaining diseases and FU for DSs.
Of course you have to always sit on a ready Blood Rune and only use to prevent BladeBarrier to fall off between pestilences. You should do so anyway to proc more F/U runes via RE.