I think that comes from the our hoarding nature from other games, which in turn results in the game becoming a loot grind. At some point you have so many diamonds in your chests over 8 bases that picking up another diamond seems tedious. It happens in all games. I've had similar things in Terraria, where I have so much loot and all the best items and that's sorta the end. The good part about Skyrim is that there is still content to experience once you've reached that point. I would be highly curious in a mod that adds more ore, more gems, and then doubles the crafting capability in combination with increasing mob difficulty. Effectively extending the playability artificially.
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When I searched for your issue, I found this:http://forums.nexusmods.com/index.ph...to-pick-locks/ Perhaps it may help?I had this same problem. Turns out I had forgotten to copy the scripts folder from the "00 - Required Scripts" folder into the data folder for Skyrim. Once I did that, it fixed the issue.