If warriors don't get a massive nerf to their armor it won't be important what any other class stacks because we'll all be playing one, its really that dumb right now in beta.
Mastery -> dodge smoothing, if you looked at physical damage taken in a graph all mastery will do is bring every other peak down by your % mastery. It won't help you survive that massive single strike unless you get lucky or if the total damage of 1 auto attack + massive strike is the real danger, not the massive strike itself.
Versatility -> lower peaks / all types of damage / unsure on healing scaling when compared to extra AP from mastery.
Except for some fights with massive amounts of elemental damage Mastery should destroy versatility. We simply dont have the rage to be using FR all that much, cutting even more into the budget quota for it. if versatility was healing taken.... well that's another story... one I would very much like to see considering it would make ursa major feel less shitty.