My PC crashes, and I get a Blue screen.
At the moment, this happens with a lot of Creative sound cards. Try using the Beta drivers on the Creative website, or by turning off sound in the game. This forum post will show you how to use Software audio. If this still doesn’t work, --nosound instead of --softwareaudio will let you disable sound entirely.
If you don’t have a Creative card, it is likely the drivers on your graphics card or other hardware. Try updating them from the manufacturer website.
Path of Exile can’t cause Blue Screens of Death, but it can trigger something in your hardware drivers that can.