I don't know the podcast to which Fencers is referring, but I personally agree with that sentiment because I'd say balance is typically not a critical factor in determining if you'll enjoy a game.
If you think of any games you've enjoyed that have multiple playable characters/classes, whether it's an ARPG like a Diablo, or MMORPG like WoW, or a fighting game, would you say it was perfectly balanced? I bet the answer would most likely be no. But that doesn't automatically mean it's bad; there are plenty of possible reasons why you may enjoy a game even if it's not balanced.
But if you were told that it were balanced or unbalanced before you tried it, do you think you would've had a better or worse impression? I can't say for certain, but I would imagine that having that knowledge beforehand would likely either decrease your impression of a game or at best keep it neutral, and never increase it.
Or alternatively, the first Street Fighter was perfectly balanced as it only had identical characters, but does that info help you judge it as being better than later Street Fighter games or any other 2d 1v1 fighter?
Thus, relating to Path of Exile, obviously not all builds are equal. Some may have an easier time than others, some may not work until you have certain uniques, some may be great for one thing but worse for another; all things you could've expected and not at all surprising. But are there tons of ways to build a character that can kill things in the endgame? Yes, and that's probably all you need to hear to consider giving the game a shot.