I don't have two 1hander equal in ilvl to my 2hander ? Would it be a bigg DPS lost ?
PVP or PVE? Because in PVE Unholy is fine, gets better as you get more gear.
The answer to your question is "it depends™". You should probably sim it, or try it, but don't forget to account for the cost of learning the new rotations, etc, even if it does better on paper.