I would think with the nerf to GoSac in 5.2 that in both single target and heavy AoE fights (read any fight where you don't use havoc basically) that the optimal choice would be to use GoSup. GoSac doesn't buff our AoE and in 5.1 on a purely single target fight a haste heavy build with GoSup was extremely close to a GoSac build with full mastery. I have no math to back this up but my current guessing is that on single target and AoE fights we will use GoSup and only on cleave fights will GoSac obviously be the best choice.