Supreme Count Appointments are pretty huge. While that's not always an immediate impact, Presidential elections are always important because of that. You also have foreign policies that can be largely impacted by the actions of the President and the SoS, and decisions and rules coming down from Cabinet Department leadership can also have a big impact on the country.
Department of the Treasury, Defense, Interior, Agriculture, Commerce, Labor, Health and Human Services, Energy (among others) can potentially have a big positive or negative impact on the welfare of the country.
Remember kids, if you vote for Hillary, it's just like giving Bernie the middle finger.
What are we gonna do now? Taking off his turban, they said, is this man a Jew?
'Cause they're working for the clampdown
They put up a poster saying we earn more than you!
When we're working for the clampdown
We will teach our twisted speech To the young believers
We will train our blue-eyed men To be young believers
The bernie bros who won't vote for hillary because they think she is some wall street puppet who is a war crazed maniac (not the ones who support Bernie for his ideas) are basically equivalent to Donald Trump supporters.
If you think $hillary will pick good replacements for SCOTUS, you're a fool. Yeah, four potential spots to fill... with more corporatist shills that are exactly the same, but have a D instead of an R.