I talked about this with some friends in length. Is it possible? Yes. Is it likely? No. The reason being is because video game prices have come to a point where no one wants to pay more than $60 unless it's a special edition of the game. If a game with no special attachments released at $80, people would lose their mind and no devs or producers would allow that to happen because it would mean less sales.
And no devs or producers would pony up for a more expensive cart and eat into their -own- profits. Back in the good ol' days of the NES and SNES, if a game took up more space than a typical cart had, they'd have to come on carts with bigger storage, and so the carts would be more expensive. I seem to remember Phantasy Star IV was like $80 when it first released because of this. Game prices were all over the place. I don't think we're in a market right now that could handle that.