Originally Posted by
Triggered Fridgekin
I'd double check your event viewer and see if it's able to identify a specific problem or it's just kicking off your standard ID 41 error while in safe mode. Is it a complete power down or does it blue screen?
What stands out to me is how it's working in both the BIOS and under safe mode since safe mode runs with many services disabled. If it's a blue screen crash (maybe even a power crash?) then it could point to one of those ultra-weird gremlins such as needing to change some power settings in the BIOS because it's causing Defender to go haywire when it's running for whatever reason so I'd have to ask what OS you're using and if you're done any recent software updates (MB BIOS, Drivers, Windows Updates).
All that being said, the RM750s built by Chicony aren't that great and you can verify if it is if the model number looks something like 75-XXXXXX. If it's RPS then it's the newer Channel Well Technologies model which are a bit better.