I've never been one to make a choice from the get-go and stick with it, so I'll probably play all the classes considerably before making up my mind.
As far as races go, I'll probably stick with Human for my Scholar and Adventurer classes, and probably Norn for my Soldiers. May even stick with Human when I try guardian, and leave Norn for my Warrior. Asura, Sylvari and Charr just don't appeal to me.
I do have to admit that I'm excited about the Mesmer. I enjoyed the Mesmer in the original Guild Wars and I love psychic themed magic. Hell, even as a kid playing Pokemon way back in the day, I tried my damnedest to build an all Psychic/Ghost team! My love for psychic themed classes is one of the many reasons why my main in World of Warcraft has been a Shadow Priest for quite some time.
The Elementalist, however, looks very tempting as well, not only having different skillsets for each weapon combo, but also for each elemental attunement on top of that. They sound quite fun.
Next, there's the Necromancer. I love playing debuffers as well, and the aesthetic of Necromancer abilities is just fantastic.
Beyond that, I'll probably mess around a little with an Engineer, and I'll probably also try a ranged Warrior and/or Thief.
As far as weapons go, I have no clue at the moment, even after checking out the skill builder. However, an Axe wielding Necromancer sounds interesting.