I once met a man in Devon who lived for a while amongst wolves, and they played with him and could be described as "rehabilitated into loving, caring dogs."; this doesn't mean that all wolves are nice? Silly example, but it should get the point about the low numbers.
22 dogs turned nice can't overrule 40.8% of the fatal dog bites in US in the past five years (recent sample, basic maths,
http://en.wikipedia.org/wiki/Fatal_d...Summary_tables) being from Pitbulls, and a second largers proportion of fatalities being from mixed breeds which could include part pitbull.
Pocho was a "domesticated" crocodile in Costa Rice, while Gustave is a crocodile who has roughly 300 deaths attributed to him; 22 dogs can't redeem a species, you need much larger amounts on tested domestication *and* proof that the dogs can't be made to be aggressive; you'd have trouble training a Chihuahua to be a fighter against other Chihuahuas, Pitbulls, not so much, and there will always be some who want aggressive dogs and thus, bad reputation?
On the topic of breeding, I think that has very little relevance compared to upbringing; take a human, evolved as we are, teach him maths, he might make a decent accountant. Take a human, while he grows up, make him do nothing but attack and be attacked, he'll be aggressive? The issue with any nasty dogs, starts with the owner.
I bothered with all of that to avoid starting work, and to shoehorn in Gustave, check him out on wikipedia!