Glyph of Unstable Affliction is usually what I will sacrifice for CoX - and CoX is of course a situational glyph itself, not something you take everytime. Most of my Soul Shards are spent on SB:SS anyways, so while I do still hardcast some UA's, the little extra time isn't too big a deal.
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You have to pick the melee who don't have crazy uptime - you can make use of portals and coil to open gaps on them - and you don't have to do it to just melee - you can SB:SS casters and hunters, and then KjC:Malefic Grasp to get a pretty powerful advantage over ranged battles as well.