Originally Posted by
Bojos
Macroing vendetta+shadowblades on the pull can't be a gain, it's not possible(if you're popping them from stealth). When you use vendetta you activate the global cooldown which means you have to wait a second before you can open with either ambush or mutilate, if you pop both vendetta and shadowblades you're wasting one second of your shadowblades buff. Vendetta-gcd ends-shadowblades+mutilate/ambush(macroing sb with your opener ambush/mutilate will be optimal here) will always be the superior option of these two.
Using a macro for sb+vendetta might lead to less human error and this can cause a dps gain, nothing practise can't fix though.
As for mutilate vs ambush, the dps difference between these two is so minor that you can't possibly tell the difference. Also the reason I advise against ambush is because for it to be worth it with the posistional requirement it would have to grant a definite dps gain. Simcraft is showing around a 200 dps loss when using ambush and shadowcraft 1k gain, so it's just really not worth using with the problems it can cause.