I believe most of us want to and try to set ourselves above our more basic instincts, including irrationality and the various fallacies and biases we have.

When you say human nature though, do you mean the more primal & basic instincts? Because I'd say that seeking enlightenment is part of our nature, but it may perhaps be more of a choice than a "drive" as evident by all the people who don't seek enlightenment. I honestly don't know.