Originally Posted by
FatLer
In most codecs it depends on coder itself. Some support only RGB, some of them - more.
Basically, using same settings as raw footage gives you a clear idea of what coder actually does to your video (this just excludes effects of turning framerate or aspect ratio down, which is always crap even if done correctly).
I personally, when working with video (medium amount of editing and fx), have plenty of time and disk space. So I always finalize my project into one big piece of raw avi file, and then render it with tiny software called 1ncoder. It has only 4 buttons, 3 of them are for quality settings. This software makes mp4 file out of avi, max quality, minimal headache.