A 6 year study of Biggest Loser contestants found in the long term their metabolism are noticeably lower than for people of their current weight.
NYT has the most indepth story of the NIH study.
Yet their experiences, while a bitter personal disappointment, have been a gift to science. A study of Season 8’s contestants has yielded surprising new discoveries about the physiology of obesity that help explain why so many people struggle unsuccessfully to keep off the weight they lose.