Originally Posted by
Freedom
I may mainly be a PvE hero like you, but even then, the biggest thing I can recommend is shift, alt and control binding. "Even" for PvE, 1 through = is not enough, and anything past 5 on the keyboard is very awkward to press. I suggest Shift+1,2,3,4,5 as abilities/CDs(especially abilities that proc/have procs e.g. Howling Blast and Freezing Fog), Shift+F,G,D,X,C,V,Q as defensives and other abilities, etc. For something like Remorseless Winter or Heroism that you want to save and NOT fatfinger, something deliberately multi-part and sort of awkward like shift+alt+e, with alt bound to a mouse button. Maybe alt+1,2,3,4 for odd CDs like AMS that are both offensive and defensive or utility. Lots of mice have extra buttons, and you don't need a fancy gaming mouse for it either. My Microsoft mouse works just fine.