Im not sure why people here are saying take epidemic. almost all the bosses are either single target or cleave. First boss: ST, Ursoc: ST, Eye boss: onlly dmg that matters is inside which is ST, Spider: Adds dont last long enough for epidemic to matter, Dragons: ST, Cenarious: Cleave/ST, Xavious: adds are so far apart that using that many runes on dotting is a waste.