Originally Posted by
Slicer299
Your talent choices don't really changes based on the shoulders. Your talent choice in Mythic+, especially at higher levels, is going to be based on the affixes. Standard Mythic+ build is still going to be Dire Stable and Stomp, even with the shoulders. But if you are dealing with something like Tyrannical, and some of the nastier bosses, you may want a single target build with Way of the Cobra and Dire Frenzy because the bosses become the priority.
There really is no specific build for specific gear sets for Mythic +. It's all going to come down to the level, the affixes and the specific dungeon and the challenges it offers.