This image should give you some idea how to bind your keys (based on my setup more or less).
W, S, A, D - standard keys for moving. Although some people use E-S-D-F, you don’t need to go down that road (although it is better in most cases, since you have more available keys to bind)
Tab key - by default it is used to target nearest enemy, and I don’t recommend changing it. Sometimes you just can’t click on the player on the battlefield, or Proximo stops working; sometimes, it just more convenient.
R - default key for replying to whispers. It’s really convenient and I never changed it.
Green keys - the most accessible keys and most easy to start with.
Yellow keys - less accessible but still close enough.
Purple keys - targets party members (default setup)
Shift, Control, Alt - marked with red color on the image. These are the modifier keys, and can be used in combination with other keys. For example, you could use “1″ for Frostbolt, and “Shift+1″ for Fireball.