Just changed the clock frequency and that's it? There is just 1 other setting you need to manually set and that is the core voltage (vCore). When motherboards are left to automatically decide the voltage for overclocked chips, some tend to throw out excessive voltage or even undervolt, causing instability. It looks like your chip will be happy with 1.32v @ 4.6ghz, so go back into BIOS and manually set it to 1.32v and you're golden. If you notice instability during Prime 95 (or whatever you use to test stability) then nudge the voltage a teeny bit higher to 1.325v, then 1.33v, etc.
All other settings can be left to auto/defaults since it's just a moderate OC.
Also keep an eye on temps
Also GUI-based BIOS's where you can use the mouse have been around since the P67 days (or maybe even earlier), it's not specific to Z77 boards or MSI boards. Though I will admit MSI's implementation is pretty good unlike *cough* Gigabyte *cough* :P