I have two saves. Really they're both the 'same' one, because I just restarted Mass Effect 2 with the same guy. I will be using this save, because it is perfect. I have: everyone loyal, everyone alive, all downloadable content, all star systems explored, and most things 'maxed' - 5/5 (some 6/6).
It was also completed on the hardest difficulty setting on the second play through. Super excited - can't wait.
This is not to say I've played the game only twice - I just have two saves.