I currently use only default raid frames plus mouseover macros, mostly because I'm trying to break my dependence on addons as my computer ages and isn't able to keep up with the game as well as it used to, until I'm able to buy a new one.
I'm doing just fine without Grid+Clique, as I used to with them. The only thing that's possibly suffering is that in order to display everything the frames are slightly larger, but I can deal with it for now, 22" screen is enough. My only gripe is that last time I tried I couldn't get SUF to work well with the default raid frames. :-\