Originally Posted by
Kael
Only GCD-capped casters or those without short-term spell-queuing will have an issue. 1-2 presses per cast doesn't generate any issues (screw instants for everyone not resource-capped). Warriors... yeah I can't play one, the stress of getting instants off on the actual GCD/CD makes me spam painfully hard. The advice in this thread definitely applies there as well, but it doesn't mean that a combat rogue trying to play the top of their game (and to be honest, ANY high-time requirement play for MOST classes) can cause RSI even without massive spamming - that just accelerates the issue.
The stretches brought up above are useful, and appropriating the mousewheel is a godsend for spamming, in my experience.