I've been reading this thread and thinking over my original point of c list comedians and trying to think who in today's acting world could have played the roles better. Male or female.
Louis CK for Murray - pure comic genius that makes the movie any good.
Daniel day for Ramis- we have to have someone that is so good we believe all this science shit
Leo decap for Aykroyd- someone with acting chops but not strong enough to carry the comedic lead
Matt Damon as Hudson- the street tough guy that isn't all that tough.
that's as far as I got on my own list. Problem is that neither Leo or Day are known for their comedy. So Damon and Louis better be phenomenal.
And don't think to deep into list. Was put together in 10 minutes while on the shitter