Applications that expect real time responses can react poorly with Nagle's algorithm. Applications such as networked multiplayer video games expect that actions in the game are sent immediately, while the algorithm purposefully delays transmission, increasing bandwidth at the expense of latency. For this reason applications with low-bandwidth time-sensitive transmissions typically use TCP_NODELAY to bypass the Nagle delay.
This algorithm interacts badly with TCP delayed acknowledgments, a feature introduced into TCP at roughly the same time in the early 1980s, but by a different group. With both algorithms enabled, applications which do two successive writes to a TCP connection, followed by a read which will not be fulfilled until after the data from the second write has reached the destination, experience a constant delay of up to 500 milliseconds, the "ACK delay". For this reason, TCP implementations usually provide applications with an interface to disable the Nagle algorithm. This is typically called the TCP_NODELAY option. It is however not recommended to disable this. A solution recommended by Nagle himself, is to keep from sending small single writes and buffer up application writes then send.