They work, but you shouldn't use more than a single command.For mouseover macros I thought the link I posted already showed the macro to do exactly that, a priority on whether to cast it on a mouse over, current target, or finally yourself. Someone did confirm that's how it worked. It will still mess up ability queueing and that's something everyone detests you are not alone there.
Healers should always use <mo>, and not include <t> <tt> <me> etc.
Tanks who want to shirk should always use <2> and if you want a specific skill for a specific party position it's best to just add a hotbar right next to the party list with the specific <#> and "click" it.
Or again, use <mo>.
As long as you don't use multiple lines, <mo> works just fine and doesn't mess up anything.
There are some workarounds for other stuffs, such as hiding your HP/MP alltogether and put yourself on focus target and use that as an HP bar for example. As a mana-less DD, you don't really need a focus target.